Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21559883 | 0.87 | SLC7A5 (0.56) | SLC7A5HDAC8HDAC6MRGPRX4KDR | |
| SCHEMBL11818 | 0.81 | PLK1 (0.61) | SLC7A5HDAC8HDAC6MRGPRX4SMN1; SMN2 | |
| SCHEMBL1569612 | 0.81 | SLC7A5 (0.60) | SLC7A5HDAC8HDAC6MRGPRX4KIF11 | |
| SCHEMBL46936 | 0.81 | FOLH1 (0.59) | MRGPRX4RAB9ASMN1; SMN2 | |
| SCHEMBL1569614 | 0.81 | SLC7A5 (0.60) | SLC7A5HDAC8HDAC6MRGPRX4NPC1 | |
| SCHEMBL20342670 | 0.81 | EPHX1 (0.51) | MRGPRX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20114775 | 0.80 | SMYD3 (0.64) | NPC1RAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL6011693 | 0.80 | LOXL2 (0.66) | SLC7A5MRGPRX4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16103849 | 0.79 | SLC7A5 (0.59) | SLC7A5HDAC8HDAC6MRGPRX4KIF11 | |
| SCHEMBL20668077 | 0.79 | PARP1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365644-A1 | ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | US | disclosed |
| US-20210206822-A1 | Cyclic Peptide Tyrosine Tyrosine Compounds as Modulators of Neuropeptide Y Receptors | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-08 | — | — | US | disclosed |
| US-10968264-B2 | Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-06 | — | — | US | disclosed |
| US-20180127476-A1 | CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210206822-A1 | Cyclic Peptide Tyrosine Tyrosine Compounds as Modulators of Neuropeptide Y Receptors | NPY4R, NPY5R, NPY1R | SLC7A5 1095/4885HDAC8 1840/4885HDAC6 1273/4885 |
| US-20180127476-A1 | CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS | NPY4R, NPY5R, NPY1R | SLC7A5 1095/4885HDAC8 1840/4885HDAC6 1273/4885 |
| US-20230365644-A1 | ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS | NPY1R, NPY5R, NPY2R | SLC7A5 2145/4885HDAC8 3731/4885HDAC6 1693/4885 |
| US-10968264-B2 | Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors | NPY4R, NPY5R, NPY1R | SLC7A5 1095/4885HDAC8 1840/4885HDAC6 1273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.