SCHEMBL2013120

SCHEMBL2013120

O=Cc1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 0.84

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.84
HDAC2 Q92769 1/20 0.48
CYP1A2 P05177 2/20 0.48
ALDH1A1 P00352 6/20 0.47
KDM4E B2RXH2 2/20 0.47
POLB P06746 1/20 0.47
MAPT P10636 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
DRD1 P21728 1/20 0.47
TYR P14679 1/20 0.46
CYP2A6 P11509 4/20 0.46
ALDH5A1 P51649 1/20 0.46
ABAT P80404 1/20 0.46
KIF11 P52732 1/20 0.42
AHR P35869 2/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1919 0.92
SCHEMBL8995751 0.89 HSD17B10 (0.94) HSD17B10CYP1A2ALDH1A1KDM4EPOLB
SCHEMBL28981622 0.89 HSD17B10 (0.94) HSD17B10CYP1A2ALDH1A1KDM4EPOLB
SCHEMBL31544783 0.89 HSD17B10 (0.94) HSD17B10CYP1A2ALDH1A1KDM4ETYR
Hydrochloric Acid SCHEMBL5255687 0.89 HSD17B10 (0.94) HSD17B10CYP1A2ALDH1A1KDM4EPOLB
SCHEMBL4391231 0.89 HSD17B10 (0.67) HSD17B10HDAC2CYP1A2ALDH1A1KDM4E
SCHEMBL10693495 0.87 HSD17B10 (0.64) HSD17B10ALDH1A1KDM4EPOLBSMN1; SMN2
Ethane SCHEMBL2154693 0.86 HSD17B10 (0.89) HSD17B10CYP1A2ALDH1A1KDM4ETYR
SCHEMBL25288128 0.86 CYP2A6 (0.58) HSD17B10ALDH1A1KDM4EDRD1TYR
SCHEMBL976904 0.86 CYP2A6 (0.58) HSD17B10ALDH1A1KDM4EDRD1TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 331 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4509178-A2 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME Melinta Therapeutics, LLC (US) 2025-02-19 EP claimed
EP-3169345-B1 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME MELINTA THERAPEUTICS LLC (US) 2025-01-29 EP claimed
CN-117658785-A Preparation method of olanzapine side chain and preparation method of olanzapine 广东新达瑞生物科技有限公司 2024-03-08 CN claimed
CN-107434823-B Purification method of oritavancin intermediate A82846B 江苏恒瑞医药股份有限公司 2021-11-16 CN claimed
CN-109053864-B Method for preparing oritavancin 丽珠集团新北江制药股份有限公司 2021-08-24 CN claimed
CN-109053865-B Method for preparing oritavancin by carboxyl protection 丽珠集团新北江制药股份有限公司 2021-04-13 CN claimed
US-10864249-B2 High purity oritavancin and method of producing same MELINTA THERAPEUTICS, INC. (US) 2020-12-15 US claimed
CN-106467570-B Reductive alkylation method of glycopeptide antibiotics 正大天晴药业集团股份有限公司 2020-04-07 CN claimed
US-20190290723-A1 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME MELINTA THERAPEUTICS INC. (US) 2019-09-26 US claimed
US-20170157206-A1 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME THE MEDICINES COMPANY (US) 2017-06-08 US claimed
EP-1075480-A1 PURIFICATION OF CARBOXALDEHYDE ELI LILLY AND COMPANY (US) 2001-02-14 EP claimed
EP-1031576-A2 Glycopeptide antibiotic derivatives ELI LILLY AND COMPANY (US) 2000-08-30 EP claimed
US-5998581-A PROVIDING SOURCE OF COPPER WHICH RESULTS IN THE INITIAL PRODUCTION OF A COPPER COMPLEX OF THE GLYCOPEPTIDE ANTIBIOTIC; REDUCTIVE ALKYLATION OF THIS COMPLEX FAVORS REGIOSELECTIVE ALKYLATION AND INCREASED YIELDS ELI LILLY AND COMPANY (US) 1999-12-07 US claimed
WO-1999057123-A1 PURIFICATION OF CARBOXALDEHYDE ELI LILLY AND COMPANY (US) 1999-11-11 WO claimed
US-5952466-A INCREASED YIELD, REGIOSELECTIVE PROCESS BY REACTING SOLUBLE COPPER COMPLEX OF ANTIBIOTIC HAVING SACCHARIDE WITH AMINE AT N4 WITH KETONE OR ALDEHYDE IN PRESENCE OF SODIUM CYANOBOROHYDRIDE OR PYRIDINE*BORANE COMPLEX ELI LILLY AND COMPANY (US) 1999-09-14 US claimed
US-5939382-A PYRIDINE-BORANE AS A REDUCING AGENT ELI LILLY AND COMPANY (US) 1999-08-17 US claimed
EP-0845478-A1 Reductive alkylation of glycopeptide antibiotics ELI LILLY AND COMPANY (US) 1998-06-03 EP claimed
EP-0845477-A1 Reducing agent for reductive alkylation of glycopeptide antibiotics ELI LILLY AND COMPANY (US) 1998-06-03 EP claimed
EP-0037697-A1 Dioxolane derivatives for use as chemical intermediates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-10-14 EP claimed
EP-0037698-A1 Benzaldehyde derivatives for use as a chemical intermediate IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-10-14 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10864249-B2 High purity oritavancin and method of producing same OSGEP, SRI, OSTC HSD17B10 2567/4885HDAC2 2165/4885CYP1A2 1961/4885
US-20170157206-A1 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME OSGEP, SRI, OSTC HSD17B10 2567/4885HDAC2 2165/4885CYP1A2 1961/4885
US-20190290723-A1 HIGH PURITY ORITAVANCIN AND METHOD OF PRODUCING SAME OSGEP, SRI, OSTC HSD17B10 2567/4885HDAC2 2165/4885CYP1A2 1961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.