Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NMT2 | O60551 | 4/20 | 0.41 |
| ▸ | NMT1 | P30419 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19978008 | 0.86 | HTR1B (0.47) | KDM4EALDH1A1MAOBMAOAPOLB | |
| SCHEMBL18611618 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1MAOBMAOAPOLB | |
| SCHEMBL20323697 | 0.84 | HTR1B (0.46) | KDM4EALDH1A1MAOBMAOACA12 | |
| SCHEMBL19959021 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1MAOBMAOAPOLB | |
| SCHEMBL31302492 | 0.79 | MAOB (0.44) | MAOBMAOACA12CA9CA1 | |
| SCHEMBL18551045 | 0.79 | MAOB (0.44) | MAOBMAOACA12CA9CA1 | |
| SCHEMBL30230211 | 0.77 | DYRK1A (0.44) | MAOBMAOACA12CA9CA1 | |
| SCHEMBL22005806 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1MAOBMAOAPOLB | |
| SCHEMBL20234211 | 0.76 | KDM4E (0.38) | KDM4EALDH1A1MAOBMAOAPOLB | |
| SCHEMBL13799428 | 0.75 | ALDH1A1 (0.50) | KDM4EALDH1A1MAOBMAOAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | KDM4E 1212/4885ALDH1A1 4249/4885MAOB 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.