Sugi Predict

Sugi Predict / Compounds / SCHEMBL20133723

SCHEMBL20133723

SCHEMBL20133723

COC(=O)c1cc(NC2CCN(c3ccccc3C#N)CC2)c(C(F)(F)F)cc1C

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 6/20 0.55
▸ RPTOR Q8N122 6/20 0.55
▸ MLST8 Q9BVC4 6/20 0.55
▸ AR P10275 2/20 0.42
▸ RBP4 P02753 3/20 0.40
▸ P2RY12 Q9H244 3/20 0.40
▸ C5AR1 P21730 1/20 0.39
▸ PTK2 Q05397 2/20 0.39
▸ BDKRB1 P46663 1/20 0.39
▸ DRD2 P14416 1/20 0.38
▸ DRD4 P21917 1/20 0.38
▸ DRD3 P35462 1/20 0.38
▸ PRKCQ Q04759 1/20 0.38
▸ PRKCD Q05655 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20133721 0.91 MTOR (0.56) MTORRPTORMLST8ARC5AR1
SCHEMBL20133701 0.89 MTOR (0.61) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20133548 0.89 MTOR (0.56) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20129666 0.89 MTOR (0.62) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20133693 0.87 MTOR (0.54) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20141296 0.86 MTOR (0.53) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20129693 0.84 MTOR (0.61) MTORRPTORMLST8BDKRB1
SCHEMBL20133856 0.83 MTOR (0.56) MTORRPTORMLST8BDKRB1DRD2
SCHEMBL20141071 0.81 MTOR (0.53) MTORRPTORMLST8DRD2DRD4
SCHEMBL20140966 0.81 MTOR (0.47) MTORRPTORMLST8BDKRB1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2018-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.