Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 6/20 | 0.68 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.68 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.68 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.45 |
| ▸ | MEF2D | Q14814 | 7/20 | 0.45 |
| ▸ | EP300 | Q09472 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133972 | 0.88 | KCNQ2 (0.79) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL3892093 | 0.88 | KCNQ2 (0.79) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL17761344 | 0.84 | KCNQ2 (0.67) | KCNQ2KCNQ3KCNQ4KCNQ5HDAC4 | |
| SCHEMBL17761733 | 0.84 | KCNQ2 (0.67) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL3106790 | 0.83 | KCNQ2 (0.69) | KCNQ2KCNQ3KCNQ4KCNQ5HDAC4 | |
| SCHEMBL30794719 | 0.83 | KCNQ2 (0.69) | KCNQ2KCNQ3KCNQ4KCNQ5HDAC4 | |
| SCHEMBL20129836 | 0.83 | KCNQ2 (0.83) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL20134020 | 0.83 | KCNQ2 (0.68) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| SCHEMBL3894160 | 0.81 | KCNQ2 (0.72) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 | |
| Ezogabine SCHEMBL4054750 | 0.81 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | HRH4, H1-10, HDAC10 | KCNQ2 1257/4885KCNQ3 1235/4885KCNQ4 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.