Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21659428 | 0.88 | HRH3 (0.68) | KDM1AHRH3HRH1LTA4HSIGMAR1 | |
| SCHEMBL22066512 | 0.87 | HRH3 (0.67) | KDM1AHRH3HRH1HRH2LTA4H | |
| SCHEMBL21659763 | 0.85 | HRH3 (0.77) | HRH3LTA4HKCNH2 | |
| SCHEMBL19048026 | 0.85 | KDM1A (0.63) | KDM1AHRH3HRH1HRH2LTA4H | |
| SCHEMBL19048182 | 0.81 | KDM1A (0.59) | KDM1AHRH3HRH1LTA4HSIGMAR1 | |
| SCHEMBL21659290 | 0.81 | HRH3 (0.79) | HRH3HRH1HRH2SIGMAR1KCNH2 | |
| SCHEMBL19047571 | 0.81 | HRH3 (0.68) | KDM1AHRH3HRH1HRH2LTA4H | |
| SCHEMBL21659281 | 0.79 | HRH3 (0.56) | KDM1AHRH3HRH1LTA4HSIGMAR1 | |
| SCHEMBL23593945 | 0.78 | ACACB (0.47) | HRH3HRH1HRH2LTA4HKCNH2 | |
| SCHEMBL5568576 | 0.78 | LTA4H (0.65) | HRH3HRH1HRH2LTA4HSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233152-B2 | LSD1 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180127369-A1 | LSD1 Inhibitors | Mirati Therapeutics, Inc. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233152-B2 | LSD1 inhibitors | KDM1B, KDM1A, KDM3A | KDM1A 2/4885HRH3 1343/4885HRH1 2699/4885 |
| US-20180127369-A1 | LSD1 Inhibitors | KDM1B, KDM1A, KDM3A | KDM1A 2/4885HRH3 1343/4885HRH1 2699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.