Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144422 | 0.79 | — | — | |
| SCHEMBL16948187 | 0.79 | KDM4E (0.33) | — | |
| SCHEMBL1697663 | 0.79 | KCNJ1 (0.37) | KCNJ1 | |
| SCHEMBL10052570 | 0.79 | ERBB2 (0.32) | — | |
| SCHEMBL1191060 | 0.74 | EGFR (0.41) | KCNJ1 | |
| SCHEMBL582880 | 0.74 | ERBB2 (0.31) | — | |
| SCHEMBL20144423 | 0.72 | BCHE (0.36) | KCNJ1 | |
| SCHEMBL16948211 | 0.72 | — | — | |
| SCHEMBL9798631 | 0.69 | EGFR (0.34) | KCNJ1 | |
| SCHEMBL20144407 | 0.69 | BCHE (0.42) | KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321259-B1 | NEW PYRAZINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | GUANGZHOU MAGPIE PHARMACEUTICAL CO LTD (CN) | 2023-10-04 | — | — | EP | disclosed |
| US-10703729-B2 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD (CN) | 2020-07-07 | — | — | US | disclosed |
| US-20190276413-A1 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD. (CN) | 2019-09-12 | — | — | US | disclosed |
| EP-3321259-A1 | NEW PYRAZINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | Guangzhou Magpie Pharmaceutical Co., Ltd. (CN) | 2018-05-16 | — | — | EP | disclosed |
| CN-105017165-B | A kind of new pyrazines derivatives and preparation method thereof and medical applications | 广州喜鹊医药有限公司 | 2018-04-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276413-A1 | Pyrazine derivative, and preparation method and medical use thereof | RYR2, RYR1, ORAI1 | KCNJ1 134/4885 |
| US-10703729-B2 | Pyrazine derivative, and preparation method and medical use thereof | RYR2, RYR1, ORAI1 | KCNJ1 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.