⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20135774 | 0.79 | KCNJ1 (0.33) | — | |
| SCHEMBL16948187 | 0.79 | KDM4E (0.33) | — | |
| SCHEMBL1697663 | 0.79 | KCNJ1 (0.37) | — | |
| SCHEMBL1191060 | 0.74 | EGFR (0.41) | — | |
| SCHEMBL8518640 | 0.74 | PDE10A (0.30) | — | |
| SCHEMBL20144423 | 0.72 | BCHE (0.36) | — | |
| SCHEMBL13840466 | 0.70 | KCNJ1 (0.33) | — | |
| SCHEMBL16948211 | 0.69 | — | — | |
| SCHEMBL9798631 | 0.69 | EGFR (0.34) | — | |
| SCHEMBL20144407 | 0.69 | BCHE (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321259-B1 | NEW PYRAZINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | GUANGZHOU MAGPIE PHARMACEUTICAL CO LTD (CN) | 2023-10-04 | — | — | EP | disclosed |
| US-10703729-B2 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD (CN) | 2020-07-07 | — | — | US | disclosed |
| US-20190276413-A1 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD. (CN) | 2019-09-12 | — | — | US | disclosed |
| EP-3321259-A1 | NEW PYRAZINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | Guangzhou Magpie Pharmaceutical Co., Ltd. (CN) | 2018-05-16 | — | — | EP | disclosed |