Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362084 | 0.80 | — | — | |
| SCHEMBL28361818 | 0.77 | KDM4E (0.45) | CCR1CCR5CCR8 | |
| SCHEMBL28361794 | 0.76 | CYP2A6 (0.46) | CCR1CCR5CCR8 | |
| SCHEMBL28051848 | 0.69 | PDPK1 (0.36) | — | |
| SCHEMBL193940 | 0.67 | — | — | |
| SCHEMBL1672214 | 0.67 | ALDH1A1 (0.34) | — | |
| SCHEMBL1671362 | 0.66 | CYP2A6 (0.30) | — | |
| SCHEMBL28358273 | 0.65 | CCR1 (0.38) | CCR1CCR5CCR8 | |
| SCHEMBL790783 | 0.64 | — | — | |
| SCHEMBL9098711 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | claimed |
| CN-110669052-B | Substituted 2-azabicyclic compounds and their use as orexin receptor modulators | 詹森药业有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-110669052-A | Substituted 2-azabicyclic compounds and their use as orexin receptor modulators | 詹森药业有限公司 | 2020-01-10 | — | — | CN | disclosed |