Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16340546 | 0.85 | SIGMAR1 (0.71) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL16340059 | 0.80 | SIGMAR1 (0.77) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL22528266 | 0.80 | SIGMAR1 (1.00) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL16340524 | 0.79 | SIGMAR1 (0.72) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL16339756 | 0.77 | SIGMAR1 (0.74) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL17782052 | 0.77 | SIGMAR1 (0.71) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL16340251 | 0.77 | SIGMAR1 (0.65) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL22528268 | 0.76 | SIGMAR1 (1.00) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL29411108 | 0.76 | SIGMAR1 (1.00) | SIGMAR1KDM4EALDH1A1ESR1PGR | |
| SCHEMBL16373146 | 0.76 | SIGMAR1 (0.71) | SIGMAR1KDM4EALDH1A1ESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013824-B1 | CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2018-05-16 | — | — | EP | claimed |