Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714343 | 0.79 | PIK3CD (0.53) | PIK3CDMAP4K4 | |
| SCHEMBL2054056 | 0.79 | PIK3CD (0.54) | PIK3CDMAP4K4 | |
| SCHEMBL17331673 | 0.78 | MAP4K4 (0.42) | PIK3CDMAP4K4PLAUAURKADAPK3 | |
| SCHEMBL17397197 | 0.77 | PIK3CD (0.44) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL2016100 | 0.76 | MAP4K4 (0.40) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL2019256 | 0.76 | MAP4K4 (0.42) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL4431751 | 0.75 | MAP4K4 (0.41) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL14842804 | 0.74 | MAP4K4 (0.37) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL2717143 | 0.74 | MAP4K4 (0.41) | PIK3CDMAP4K4AURKADAPK3JAK2 | |
| SCHEMBL20119671 | 0.74 | AURKA (0.52) | MAP4K4AURKADAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075643-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |