Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016100 | 0.86 | MAP4K4 (0.40) | MAP4K4PIK3CDPIK3CGSYKLMNA | |
| SCHEMBL2015901 | 0.81 | MAPK1 (0.48) | MAP4K4PIK3CDPIK3CGSYKLMNA | |
| SCHEMBL2051140 | 0.81 | PIK3CD (0.45) | MAP4K4PIK3CDPIK3CGSYKLMNA | |
| SCHEMBL2014889 | 0.79 | PIK3CD (0.49) | MAP4K4PIK3CDPIK3CG | |
| SCHEMBL2014148 | 0.79 | PIK3CD (0.47) | MAP4K4PIK3CDPIK3CGSYKLMNA | |
| SCHEMBL17165550 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CG | |
| Hydrochloric Acid SCHEMBL18228629 | 0.77 | PIK3CD (0.55) | PIK3CDPIK3CG | |
| SCHEMBL2714343 | 0.77 | PIK3CD (0.53) | MAP4K4PIK3CDPIK3CG | |
| SCHEMBL2014851 | 0.76 | PIK3CD (0.46) | MAP4K4PIK3CDPIK3CGSYKLMNA | |
| SCHEMBL8573 | 0.76 | PIK3CD (0.54) | MAP4K4PIK3CDPIK3CGSYKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |