Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 6/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.39 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635745 | 0.99 | SCNN1A (0.42) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2015492 | 0.94 | SCNN1A (0.43) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635757 | 0.93 | SCNN1A (0.43) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2053822 | 0.90 | SCNN1A (0.36) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2043292 | 0.88 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2016181 | 0.87 | SCNN1A (0.38) | SCNN1AMAPTSMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL2053125 | 0.87 | DRD5 (0.38) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12636291 | 0.87 | SCNN1A (0.45) | SCNN1ADRD5SCNN1BSCNN1GHRH3 | |
| SCHEMBL12635760 | 0.86 | SCNN1A (0.38) | SCNN1AMAPTSMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL2020382 | 0.86 | SCNN1A (0.44) | SCNN1ADRD5SCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |