Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 5/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138233 | 0.92 | GALR3 (0.36) | GALR3SMN1; SMN2ALDH1A1PROKR1TRPV3 | |
| SCHEMBL20137950 | 0.90 | GALR3 (0.37) | GALR3SMN1; SMN2MAP3K12USP1ALDH1A1 | |
| SCHEMBL18305075 | 0.86 | CYP11B2 (0.34) | SMN1; SMN2MAP3K12ALDH1A1MAPTLMNA | |
| SCHEMBL20138091 | 0.85 | GALR3 (0.35) | GALR3SMN1; SMN2MAP3K12ALDH1A1BRD4 | |
| SCHEMBL20138285 | 0.82 | GALR3 (0.36) | GALR3SMN1; SMN2MAP3K12USP1ALDH1A1 | |
| SCHEMBL20138158 | 0.82 | GALR3 (0.37) | GALR3SMN1; SMN2ALDH1A1PROKR1TRPV3 | |
| SCHEMBL20138199 | 0.75 | CYP11B2 (0.35) | SMN1; SMN2MAP3K12ALDH1A1MAPTLMNA | |
| SCHEMBL20138155 | 0.71 | CYP11B1 (0.34) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20137999 | 0.71 | TSHR (0.35) | SMN1; SMN2MAP3K12ALDH1A1MAPTLMNA | |
| SCHEMBL20138135 | 0.71 | GRM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |
| US-10287299-B2 | Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity | UCB BIOPHARMA SPRL (BE) | 2019-05-14 | — | — | US | disclosed |
| US-20180134728-A1 | Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity | UCB S.A. (BE) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134728-A1 | Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity | TNF, NFKBIA, TNFRSF1A | GALR3 1922/4885SMN1; SMN2 798/4885MAP3K12 473/4885 |
| US-10287299-B2 | Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity | TNF, TNFRSF1A, NFKBIA | GALR3 1578/4885SMN1; SMN2 419/4885MAP3K12 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.