Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138801 | 1.00 | GSK3B (0.51) | GSK3BGSK3AP2RX7PIM1MAPT | |
| SCHEMBL20138814 | 0.89 | GSK3A (0.51) | GSK3BGSK3AP2RX7PIM1PIM2 | |
| SCHEMBL20138815 | 0.89 | GSK3A (0.51) | GSK3BGSK3AP2RX7PIM1PIM2 | |
| SCHEMBL20139008 | 0.84 | LMNA (0.52) | GSK3BGSK3AP2RX7MAPTHSD17B10 | |
| SCHEMBL20139011 | 0.84 | LMNA (0.52) | GSK3BGSK3AP2RX7MAPTHSD17B10 | |
| SCHEMBL20138817 | 0.81 | KCNH2 (0.51) | GSK3BGSK3AMAPT | |
| SCHEMBL20138818 | 0.81 | KCNH2 (0.51) | GSK3BGSK3AMAPT | |
| SCHEMBL20138847 | 0.80 | GSK3A (0.56) | GSK3BGSK3AMAPTMCL1KMT2A | |
| SCHEMBL20138846 | 0.80 | GSK3A (0.56) | GSK3BGSK3AMAPTMCL1KMT2A | |
| SCHEMBL18208170 | 0.78 | GSK3B (0.58) | GSK3BGSK3AMAPTKMT2AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |