Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138812 | 1.00 | GRM4 (0.44) | GRM4HPGDCHRM4ALOX15PDE4B | |
| SCHEMBL20143024 | 0.86 | CCNA2 (0.49) | HPGDALOX15PDE4BKDM4EHSD17B10 | |
| SCHEMBL20143023 | 0.86 | CCNA2 (0.49) | HPGDALOX15PDE4BKDM4EHSD17B10 | |
| SCHEMBL20139001 | 0.84 | KDM4E (0.61) | HPGDCHRM4KDM4EHSD17B10RXFP1 | |
| SCHEMBL20138999 | 0.84 | KDM4E (0.61) | HPGDCHRM4KDM4EHSD17B10RXFP1 | |
| SCHEMBL18209027 | 0.82 | IRAK4 (0.50) | HPGDKDM4EHSD17B10 | |
| SCHEMBL18209030 | 0.82 | IRAK4 (0.50) | HPGDKDM4EHSD17B10 | |
| SCHEMBL18208682 | 0.82 | PIK3CD (0.45) | HPGDPDE4B | |
| SCHEMBL18208683 | 0.82 | PIK3CD (0.45) | HPGDPDE4B | |
| SCHEMBL17460363 | 0.80 | APOBEC3A (0.60) | CHRM4PDE4BKDM4EHSD17B10HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |