Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143023 | 1.00 | CCNA2 (0.49) | CCNA2CDK2KDM4EHSD17B10TP53 | |
| SCHEMBL20138812 | 0.86 | GRM4 (0.44) | KDM4EHSD17B10MAPTHPGDALOX15 | |
| SCHEMBL20138810 | 0.86 | GRM4 (0.44) | KDM4EHSD17B10MAPTHPGDALOX15 | |
| SCHEMBL18208181 | 0.83 | EPHB3 (0.56) | KDM4EHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL18208178 | 0.83 | EPHB3 (0.56) | KDM4EHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL20142935 | 0.82 | NPC1 (0.56) | KDM4EHSD17B10MAPTALDH1A1NPC1 | |
| SCHEMBL20142939 | 0.82 | NPC1 (0.56) | KDM4EHSD17B10MAPTALDH1A1NPC1 | |
| SCHEMBL20138999 | 0.80 | KDM4E (0.61) | KDM4EHSD17B10MAPTALDH1A1RAB9A | |
| SCHEMBL20139001 | 0.80 | KDM4E (0.61) | KDM4EHSD17B10MAPTALDH1A1RAB9A | |
| SCHEMBL20142934 | 0.79 | HPGD (0.48) | TP53ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |