Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566584 | 0.87 | MET (0.70) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL2572332 | 0.84 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12693351 | 0.82 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12689728 | 0.82 | MET (0.78) | METPDE3BPDE3ACYP2C9PDE10A | |
| Pf-04217903 SCHEMBL29355971 | 0.82 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| Pf-04217903 SCHEMBL29394198 | 0.82 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| Pf-04217903 SCHEMBL93550 | 0.82 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL2572670 | 0.82 | MET (0.56) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12487526 | 0.81 | MET (0.77) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12487531 | 0.81 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018383-B1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | PFIZER PROD INC (US) | 2011-11-09 | — | — | EP | claimed |
| WO-2011067189-A2 | CMET INHIBITORS FOR TREATING ENDOMETRIOSIS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-09 | — | — | WO | claimed |
| WO-2011067189-A2 | CMET INHIBITORS FOR TREATING ENDOMETRIOSIS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-09 | — | — | WO | disclosed |