Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28270633 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL7701023 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7701027 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28642155 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5928128 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL6118156 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5928135 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6118163 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5928125 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL28263588 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103208610-B | Cathode for a cell of a lithium-ion battery, its manufacturing process and the battery incorporating same | 哈金森公司 | 2017-03-22 | — | — | CN | claimed |
| CN-106471651-A | Positive electrode material for secondary battery and method for preparing same | 株式会社LG 化学 | 2017-03-01 | — | — | CN | claimed |
| EP-2512536-A1 | A CALCIUM PHOSPHATE BONE CEMENT, PROCESS FOR ITS PREPARATION AND USES THEREOF | Merello, Luisa (IT) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073860-A1 | A CALCIUM PHOSPHATE BONE CEMENT, PROCESS FOR ITS PREPARATION AND USES THEREOF | MERELLO LUISA (IT) | 2011-06-23 | — | — | WO | claimed |
| CN-103208610-B | Cathode for a cell of a lithium-ion battery, its manufacturing process and the battery incorporating same | 哈金森公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-106471651-A | Positive electrode material for secondary battery and method for preparing same | 株式会社LG 化学 | 2017-03-01 | — | — | CN | disclosed |
| CN-103080385-B | Galvanized carbon steel with finished stainless steel-like characteristics | AK钢铁产权公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105810279-A | Fluorine-containing and/or fluorine radioactive waste glass ceramic solidified body and preparation method thereof | 中国科学院上海应用物理研究所 | 2016-07-27 | — | — | CN | disclosed |
| CN-105777101-A | Zirconium sodium phosphate-monazite glass ceramic solidified body and preparation method thereof | 西南科技大学 | 2016-07-20 | — | — | CN | disclosed |
| US-9271983-B2 | Composition for enhancing athletic performance | BIOADATP, LLC (US) | 2016-03-01 | — | — | US | disclosed |
| US-8999401-B2 | Delivery system and method to deliver homeopathic complexes comprising homeopathic colored pigment products for cosmetic use | LURIA HENRY STEVEN (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130261127-A1 | COMPOSITION FOR ENHANCING ATHLETIC PERFORMANCE | BIOADATP, LLC | 2013-10-03 | — | — | US | disclosed |
| US-20130101704-A1 | COMPOSITION FOR ENHANCING ATHLETIC PERFORMANCE | BIOADA TP LLC | 2013-04-25 | — | — | US | disclosed |
| US-8344032-B2 | Composition for enhancing athletic performance | BIOADA TP LLC | 2013-01-01 | — | — | US | disclosed |
| EP-2512536-A1 | A CALCIUM PHOSPHATE BONE CEMENT, PROCESS FOR ITS PREPARATION AND USES THEREOF | Merello, Luisa (IT) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073860-A1 | A CALCIUM PHOSPHATE BONE CEMENT, PROCESS FOR ITS PREPARATION AND USES THEREOF | MERELLO LUISA (IT) | 2011-06-23 | — | — | WO | disclosed |
| US-20090297643-A1 | BOTANICAL COMPOSITION AND ITS USES | MICRO-DOSE LIFE SCIENCES, LLC (US) | 2009-12-03 | — | — | US | disclosed |
| US-20080279902-A1 | Therapy for skins damage by aging or solar radiation; complex containing colored pigments; topical applying; cosmetics | LURIA HENRY STEVEN | 2008-11-13 | — | — | US | disclosed |