Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138856 | 1.00 | HPGD (0.50) | HPGDGRM4CHRM4KMT2ARAB9A | |
| SCHEMBL20142934 | 0.80 | HPGD (0.48) | HPGDGRM4KMT2ARAB9AALOX15 | |
| SCHEMBL20142932 | 0.80 | HPGD (0.48) | HPGDGRM4KMT2ARAB9AALOX15 | |
| SCHEMBL18208241 | 0.79 | HPGD (0.56) | HPGDCHRM4KMT2ARAB9AMAPT | |
| SCHEMBL18208239 | 0.79 | HPGD (0.56) | HPGDCHRM4KMT2ARAB9AMAPT | |
| SCHEMBL20142963 | 0.78 | HPGD (0.46) | HPGDGRM4CHRM4GSK3AGSK3B | |
| SCHEMBL20142964 | 0.78 | HPGD (0.46) | HPGDGRM4CHRM4GSK3AGSK3B | |
| SCHEMBL18216438 | 0.78 | HPGD (0.55) | HPGDGRM4CHRM4KMT2ARAB9A | |
| SCHEMBL20138986 | 0.78 | HPGD (0.47) | HPGDGRM4CHRM4KMT2AALOX15 | |
| SCHEMBL20138984 | 0.78 | HPGD (0.47) | HPGDGRM4CHRM4KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |