Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142964 | 1.00 | HPGD (0.46) | HPGDGRM4PDE4BGSK3AGSK3B | |
| SCHEMBL20142934 | 0.86 | HPGD (0.48) | HPGDGRM4PDE4BPOLB | |
| SCHEMBL20142932 | 0.86 | HPGD (0.48) | HPGDGRM4PDE4BPOLB | |
| SCHEMBL20142977 | 0.83 | HPGD (0.50) | HPGDGRM4PDE4BMAPTABL1 | |
| SCHEMBL20142976 | 0.83 | HPGD (0.50) | HPGDGRM4PDE4BMAPTABL1 | |
| SCHEMBL20161124 | 0.80 | HPGD (0.47) | HPGDGRM4PDE4BGSK3AGSK3B | |
| SCHEMBL20138984 | 0.80 | HPGD (0.47) | HPGDGRM4MAPTCHRM4POLB | |
| SCHEMBL20138986 | 0.80 | HPGD (0.47) | HPGDGRM4MAPTCHRM4POLB | |
| SCHEMBL5265617 | 0.79 | KDM4E (0.58) | PDE4BPDE4D | |
| SCHEMBL20138810 | 0.79 | GRM4 (0.44) | HPGDGRM4PDE4BGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |