Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159196 | 0.89 | PDE4B (0.43) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20159102 | 0.84 | PDE4B (0.39) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20159457 | 0.84 | PDE4B (0.39) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20159121 | 0.84 | PDE4B (0.39) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20159108 | 0.82 | PDE4B (0.38) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL20142921 | 0.80 | PDE4B (0.40) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20159428 | 0.80 | PDE4B (0.40) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL22923656 | 0.79 | TNF (0.43) | PDE4BPDE3AHRH3PDE4APDE4C | |
| SCHEMBL20143661 | 0.79 | CD274 (0.45) | PDE3AHRH3PDE4DACHEPDE3B | |
| SCHEMBL25095015 | 0.79 | PDE4B (0.37) | PDE4BPDE3APDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |