Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159196 | 0.80 | PDE4B (0.43) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL20159108 | 0.80 | PDE4B (0.38) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL22923575 | 0.78 | PDE3A (0.43) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL20142921 | 0.78 | PDE4B (0.40) | PDE3APDE3BPDE4BLMNAPDE4A | |
| SCHEMBL20159457 | 0.78 | PDE4B (0.39) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL22923519 | 0.78 | NAMPT (0.51) | — | |
| SCHEMBL25095015 | 0.77 | PDE4B (0.37) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL22923624 | 0.77 | ITGB1 (0.37) | LMNAPOLBALDH1A1 | |
| SCHEMBL22923673 | 0.75 | MEN1 (0.35) | PDE3APDE3BPDE4BTSHRALDH1A1 | |
| SCHEMBL20159430 | 0.73 | PDE4B (0.38) | PDE3APDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013693-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-01-28 | — | — | WO | disclosed |