Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150470 | 0.85 | EGFR (0.57) | JAK2JAK3BTKEGFRERBB2 | |
| SCHEMBL20139048 | 0.85 | SRC (0.59) | JAK3JAK1SRCBTKEGFR | |
| SCHEMBL20143667 | 0.84 | PIK3CD (0.56) | JAK3SRCBTKEGFRPIK3CD | |
| SCHEMBL21484334 | 0.83 | ERBB2 (0.62) | JAK2JAK3SRCEGFRERBB2 | |
| SCHEMBL20138979 | 0.83 | BTK (0.54) | JAK3SRCKITBTKEGFR | |
| SCHEMBL20139785 | 0.81 | SRC (0.58) | SRCBTKEGFRPIK3CDERBB2 | |
| SCHEMBL20139002 | 0.80 | PIK3CD (0.55) | JAK3SRCBTKEGFRPIK3CD | |
| SCHEMBL20150708 | 0.80 | PIK3CD (0.54) | JAK3SRCBTKEGFRPIK3CD | |
| SCHEMBL29538618 | 0.80 | JAK1 (0.59) | JAK2JAK3JAK1BTKEGFR | |
| SCHEMBL20139429 | 0.80 | JAK1 (0.59) | JAK2JAK3JAK1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018088780-A1 | NOVEL PYRROLOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-05-17 | — | — | WO | disclosed |