Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139350 | 1.00 | MTOR (0.47) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20139828 | 0.86 | MTOR (0.49) | MTORRPTORMLST8SCD5NPC1 | |
| SCHEMBL20142359 | 0.80 | MTOR (0.45) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20154261 | 0.80 | MTOR (0.47) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20140002 | 0.77 | CHRM4 (0.40) | MTORRPTORMLST8CHRM4KMT2A | |
| SCHEMBL20140004 | 0.77 | CHRM4 (0.40) | MTORRPTORMLST8CHRM4KMT2A | |
| SCHEMBL20139265 | 0.76 | MTOR (0.52) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20159083 | 0.75 | MTOR (0.57) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20159033 | 0.75 | MTOR (0.57) | MTORRPTORMLST8SCD5CHRM4 | |
| SCHEMBL20159032 | 0.75 | MTOR (0.57) | MTORRPTORMLST8SCD5CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |