Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.33 |
| ▸ | CHRNG | P07510 | 2/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRND | Q07001 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139590 | 1.00 | RORC (0.48) | RORCNR1I2DRD1NPY5RCHRNA1 | |
| SCHEMBL20139610 | 0.86 | RORC (0.57) | RORCNR1I2DRD1NPY5RCHRNA1 | |
| SCHEMBL20139691 | 0.86 | RORC (0.57) | RORCNR1I2DRD1NPY5RCHRNA1 | |
| SCHEMBL20149299 | 0.84 | RORC (0.51) | RORCNR1I2DRD1CHRNA1CHRNG | |
| SCHEMBL20139577 | 0.84 | RORC (0.51) | RORCNR1I2DRD1CHRNA1CHRNG | |
| SCHEMBL20139575 | 0.84 | RORC (0.51) | RORCNR1I2DRD1CHRNA1CHRNG | |
| Trifluoroacetic Acid SCHEMBL20139646 | 0.78 | RORC (0.52) | RORCNR1I2SLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL20139647 | 0.78 | RORC (0.52) | RORCNR1I2SLC6A2SLC6A3 | |
| SCHEMBL23713083 | 0.77 | RORC (0.46) | RORCNR1I2DRD1 | |
| SCHEMBL20139645 | 0.72 | RORC (0.55) | RORCNR1I2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |