Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140231 | 1.00 | RORC (0.69) | RORCNR1I2CCR5SIGMAR1 | |
| SCHEMBL20141240 | 0.86 | RORC (0.64) | RORCNR1I2CCR5 | |
| SCHEMBL23683614 | 0.82 | RORC (0.72) | RORCCCR5SIGMAR1 | |
| SCHEMBL23683607 | 0.82 | RORC (0.72) | RORCCCR5SIGMAR1 | |
| SCHEMBL20139548 | 0.82 | RORC (0.72) | RORCCCR5SIGMAR1 | |
| SCHEMBL23713088 | 0.82 | RORC (1.00) | RORCNR1I2 | |
| SCHEMBL23683609 | 0.80 | RORC (0.60) | RORCCCR5SIGMAR1 | |
| SCHEMBL20139553 | 0.80 | RORC (0.60) | RORCCCR5SIGMAR1 | |
| SCHEMBL20139695 | 0.77 | RORC (0.60) | RORCNR1I2 | |
| SCHEMBL23713089 | 0.77 | RORC (1.00) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |