Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159024 | 0.88 | MTOR (0.64) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159036 | 0.87 | MTOR (0.58) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20159120 | 0.87 | MTOR (0.55) | MTORRPTORMLST8CHRM4DRD2 | |
| SCHEMBL20158919 | 0.84 | MTOR (0.72) | MTORRPTORMLST8CHRM4FNTA | |
| SCHEMBL20159123 | 0.84 | MTOR (0.69) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159286 | 0.83 | MTOR (0.51) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159115 | 0.83 | MTOR (0.55) | MTORRPTORMLST8HTR7POLB | |
| SCHEMBL20159165 | 0.82 | MTOR (0.51) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159079 | 0.82 | MTOR (0.52) | MTORRPTORMLST8CHRM4HTR7 | |
| SCHEMBL20139510 | 0.82 | MTOR (0.68) | MTORRPTORMLST8CHRM4FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |