Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370341 | 0.88 | PDE5A (0.52) | PDE5ATDP1L3MBTL1ADORA2AADORA1 | |
| SCHEMBL20140367 | 0.86 | TDP1 (0.45) | PDE5ATDP1L3MBTL1ADORA2AADORA1 | |
| SCHEMBL21775364 | 0.83 | ALDH1A1 (0.41) | PDE5AADORA2AADORA1 | |
| SCHEMBL2881224 | 0.78 | PDE5A (0.42) | PDE5AL3MBTL1 | |
| SCHEMBL15111735 | 0.76 | PDE5A (0.55) | PDE5AADORA2AADORA1 | |
| SCHEMBL16370487 | 0.76 | PDE5A (0.53) | PDE5AADORA2AADORA1 | |
| SCHEMBL174888 | 0.76 | PDE5A (0.48) | PDE5A | |
| SCHEMBL30745084 | 0.76 | PDE5A (0.48) | PDE5A | |
| SCHEMBL14746447 | 0.74 | PDE5A (0.54) | PDE5ATDP1L3MBTL1ADORA2AADORA1 | |
| SCHEMBL14746488 | 0.74 | PDE5A (0.52) | PDE5ATDP1L3MBTL1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |