Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.58 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.58 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159014 | 0.91 | MTOR (0.58) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20139243 | 0.87 | MTOR (0.55) | MTORRPTORMLST8KMT2AHTR7 | |
| SCHEMBL20139244 | 0.87 | MTOR (0.55) | MTORRPTORMLST8KMT2AHTR7 | |
| SCHEMBL20140555 | 0.84 | MTOR (0.78) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159141 | 0.83 | MTOR (0.64) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20158992 | 0.81 | MTOR (0.84) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159096 | 0.80 | MTOR (0.60) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159001 | 0.78 | MTOR (0.55) | MTORRPTORMLST8KMT2AHTR7 | |
| SCHEMBL20139236 | 0.78 | MTOR (0.68) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20140500 | 0.77 | MTOR (0.67) | MTORRPTORMLST8HTR7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |