Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.50 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140021 | 0.88 | PRKAA2 (0.42) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20140739 | 0.82 | PARP1 (0.51) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20140631 | 0.82 | MTOR (0.56) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20139928 | 0.78 | MTOR (0.56) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20156931 | 0.78 | MTOR (0.51) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20156824 | 0.78 | MTOR (0.56) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20139960 | 0.77 | MTOR (0.56) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20157185 | 0.77 | KDM4E (0.43) | MTORRPTORMLST8RORC | |
| SCHEMBL20141000 | 0.76 | MTOR (0.52) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20140044 | 0.75 | MTOR (0.54) | MTORRPTORMLST8TACR3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |