Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140068 | 0.87 | HTR2A (0.42) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20139486 | 0.87 | HTR2A (0.40) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20139480 | 0.86 | CHRNA7 (0.44) | HTR2AHTR2CHRH3CHRNA7RAB9A | |
| SCHEMBL20140108 | 0.85 | HTR2A (0.41) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20140136 | 0.85 | HTR2A (0.40) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20141585 | 0.82 | HTR2A (0.42) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20139949 | 0.82 | RAB9A (0.47) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20139642 | 0.81 | HTR2A (0.37) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 | |
| SCHEMBL20139430 | 0.80 | EPHX2 (0.33) | KMT2AALDH1A1 | |
| SCHEMBL20141555 | 0.77 | HTR2A (0.44) | HTR2AHTR2CHRH3CHRNA7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-27 | — | — | US | disclosed |
| WO-2018089449-A1 | BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | SLC5A2, SLC5A1, SLC2A2 | HTR2A 862/4885HTR2C 879/4885HRH3 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.