Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 14/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.43 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21314474 | 1.00 | ITGAV (0.46) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL21314477 | 1.00 | ITGAV (0.46) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL28744049 | 0.89 | ITGB3 (0.37) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL30487525 | 0.89 | ITGB3 (0.37) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL20158223 | 0.89 | ITGB3 (0.37) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL21314435 | 0.87 | ITGAV (0.43) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL21314434 | 0.87 | ITGAV (0.43) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL20140498 | 0.87 | ITGAV (0.43) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL20140602 | 0.87 | ITGAV (0.43) | ITGAVITGB3ITGB1ITGB6ITGA2B | |
| SCHEMBL20141198 | 0.84 | ITGAV (0.48) | ITGAVITGB3ITGB1ITGB6ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |