Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140725 | 0.91 | MTOR (0.47) | MTORRPTORMLST8NAMPTPARP1 | |
| SCHEMBL20139945 | 0.88 | MTOR (0.49) | MTORRPTORMLST8NAMPTPARP1 | |
| SCHEMBL20141373 | 0.86 | MTOR (0.49) | MTORRPTORMLST8PARP1DRD4 | |
| SCHEMBL20140200 | 0.85 | MTOR (0.59) | MTORRPTORMLST8NAMPTPARP1 | |
| SCHEMBL20140818 | 0.83 | P2RX7 (0.46) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20139962 | 0.81 | MTOR (0.55) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20156918 | 0.81 | MTOR (0.55) | MTORRPTORMLST8NAMPTPARP1 | |
| SCHEMBL20156824 | 0.80 | MTOR (0.56) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20140235 | 0.80 | MTOR (0.67) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20140824 | 0.80 | MTOR (0.67) | MTORRPTORMLST8DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |