Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141062 | 0.86 | FNTA (0.33) | IDH1ITGAV | |
| SCHEMBL24521894 | 0.84 | HDAC1 (0.33) | IDH1ITGB3ITGAVITGB5 | |
| SCHEMBL24521883 | 0.84 | HDAC1 (0.33) | IDH1ITGB3ITGAVITGB5 | |
| SCHEMBL20140045 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL20140041 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL20140049 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL20141294 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL20153509 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL21294622 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 | |
| SCHEMBL29797302 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |