Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 11/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 7/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | OXGR1 | Q96P68 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142767 | 0.92 | ITGB3 (0.40) | ITGB3ITGAVITGA2BITGB6SUCNR1 | |
| SCHEMBL29797239 | 0.92 | ITGB3 (0.40) | ITGB3ITGAVITGA2BITGB6SUCNR1 | |
| SCHEMBL20141912 | 0.80 | CTSA (0.38) | ITGB3ITGAVITGA2BITGB6CTSA | |
| SCHEMBL21294620 | 0.80 | CTSA (0.38) | ITGB3ITGAVITGA2BITGB6CTSA | |
| SCHEMBL20140302 | 0.79 | ITGB3 (0.38) | ITGB3ITGAVITGA2BITGB6SUCNR1 | |
| SCHEMBL20140538 | 0.79 | ITGAV (0.65) | ITGB3ITGAVITGA2BITGB6 | |
| SCHEMBL20139938 | 0.79 | ITGAV (0.65) | ITGB3ITGAVITGA2BITGB6 | |
| SCHEMBL20139714 | 0.79 | ITGAV (0.65) | ITGB3ITGAVITGA2BITGB6 | |
| SCHEMBL21311604 | 0.79 | SUCNR1 (0.38) | ITGB3ITGAVITGA2BITGB6CTSA | |
| SCHEMBL20139608 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGA2BITGB6CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |