Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.70 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.70 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140260 | 1.00 | MTOR (0.70) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140539 | 0.97 | MTOR (0.74) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140540 | 0.97 | MTOR (0.74) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20159161 | 0.90 | MTOR (0.64) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20159146 | 0.88 | MTOR (0.68) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20141653 | 0.88 | MTOR (0.71) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20141650 | 0.88 | MTOR (0.71) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20140249 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140252 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20139510 | 0.86 | MTOR (0.68) | MTORRPTORMLST8DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |