Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140252 | 1.00 | MTOR (0.60) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140493 | 0.92 | MTOR (0.56) | MTORRPTORMLST8CHRM1TRPV1 | |
| SCHEMBL20140492 | 0.92 | MTOR (0.56) | MTORRPTORMLST8CHRM1TRPV1 | |
| SCHEMBL20140539 | 0.89 | MTOR (0.74) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140540 | 0.89 | MTOR (0.74) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20141008 | 0.88 | MTOR (0.72) | MTORRPTORMLST8CHRM4DRD2 | |
| SCHEMBL20140260 | 0.87 | MTOR (0.70) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20140258 | 0.87 | MTOR (0.70) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20142009 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM2CHRM1 | |
| SCHEMBL20142006 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |