Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 19/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.47 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21294608 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL21294590 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20139505 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL21294589 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL29797060 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20139506 | 0.81 | ITGB3 (0.47) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL21294625 | 0.80 | ITGB3 (0.42) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20141872 | 0.80 | ITGB3 (0.42) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL21294623 | 0.80 | ITGB3 (0.42) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20141869 | 0.80 | ITGB3 (0.42) | ITGAVITGB3ITGB1ITGA5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | claimed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | claimed |