Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158933 | 0.90 | HRH3 (0.47) | MTORRPTORMLST8HRH3ATM | |
| SCHEMBL20159024 | 0.90 | MTOR (0.64) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159166 | 0.89 | POLB (0.55) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159007 | 0.89 | POLB (0.55) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159123 | 0.87 | MTOR (0.69) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20158948 | 0.86 | MTOR (0.49) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159115 | 0.82 | MTOR (0.55) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159302 | 0.80 | TP53 (0.53) | DRD2HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL20159079 | 0.80 | MTOR (0.52) | MTORRPTORMLST8HRH3HTR7 | |
| SCHEMBL20159286 | 0.79 | MTOR (0.51) | MTORRPTORMLST8HRH3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |