Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 12/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16544582 | 0.88 | GRM5 (0.59) | PDK4GRM5GRM1HTR1ADRD2 | |
| SCHEMBL28930727 | 0.86 | PDK4 (0.47) | PDK4GRM5GRM1NAMPT | |
| SCHEMBL3466674 | 0.85 | GRM1 (0.46) | PDK4GRM5GRM1NAMPT | |
| SCHEMBL24793335 | 0.84 | PDK4 (0.45) | PDK4GRM5GRM1NAMPTGPR119 | |
| SCHEMBL29899506 | 0.84 | IDH1 (0.48) | PDK4GRM5GRM1HTR1ADRD2 | |
| SCHEMBL3466461 | 0.83 | PDK4 (0.44) | PDK4GRM5GRM1NAMPTGPR119 | |
| SCHEMBL20140921 | 0.81 | HTR1A (0.45) | GRM5HTR1ADRD2DRD4 | |
| SCHEMBL31334406 | 0.81 | GRM5 (0.55) | PDK4GRM5GRM1NAMPTGPR119 | |
| SCHEMBL29899534 | 0.81 | GRM1 (0.45) | PDK4GRM5GRM1NAMPTGPR119 | |
| SCHEMBL30308912 | 0.80 | GRM1 (0.64) | PDK4GRM5GRM1NAMPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |