Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 16/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.36 |
| ▸ | ITGB6 | P18564 | 10/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140148 | 0.85 | ITGB3 (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL20141460 | 0.80 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL20153423 | 0.80 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL29797098 | 0.80 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL29797207 | 0.80 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL20140790 | 0.80 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL21294589 | 0.79 | ITGB3 (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL21294608 | 0.79 | ITGB3 (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL21294590 | 0.79 | ITGB3 (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL20139506 | 0.79 | ITGB3 (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | claimed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | claimed |