Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140897 | 0.89 | MTOR (0.45) | MTORRPTORMLST8MAPK1PARP1 | |
| SCHEMBL20141546 | 0.85 | MTOR (0.47) | MTORRPTORMLST8 | |
| SCHEMBL20139914 | 0.84 | MTOR (0.53) | MTORRPTORMLST8PARP1HTR1A | |
| SCHEMBL20140782 | 0.80 | CHRM4 (0.44) | MTORRPTORMLST8HTR1A | |
| SCHEMBL20139884 | 0.78 | BDKRB1 (0.47) | MTORRPTORMLST8 | |
| SCHEMBL20157274 | 0.78 | MTOR (0.49) | MTORRPTORMLST8PARP1PHGDH | |
| SCHEMBL20141526 | 0.77 | MTOR (0.50) | MTORRPTORMLST8PHGDHCFTR | |
| SCHEMBL20141050 | 0.77 | MTOR (0.46) | MTORRPTORMLST8PARP1 | |
| SCHEMBL20140200 | 0.77 | MTOR (0.59) | MTORRPTORMLST8PARP1 | |
| SCHEMBL20156963 | 0.76 | GBA1 (0.45) | MTORRPTORMLST8PARP1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |