Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140950 | 0.89 | MTOR (0.49) | MTORRPTORMLST8PHGDHMAPK1 | |
| SCHEMBL20156963 | 0.85 | GBA1 (0.45) | MTORRPTORMLST8PHGDHPARP1 | |
| SCHEMBL20140304 | 0.85 | GBA1 (0.44) | MTORRPTORMLST8PHGDHPARP1 | |
| SCHEMBL20157255 | 0.82 | MTOR (0.40) | MTORRPTORMLST8PHGDHMAPK1 | |
| SCHEMBL20140777 | 0.81 | DRD4 (0.43) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20141538 | 0.81 | DRD4 (0.41) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140336 | 0.80 | MAPT (0.47) | MTORRPTORMLST8CYP2C9CYP2C19 | |
| SCHEMBL20157066 | 0.78 | MTOR (0.46) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20141292 | 0.78 | BDKRB1 (0.47) | MTORRPTORMLST8CYP2C9CYP2C19 | |
| SCHEMBL20157539 | 0.77 | MTOR (0.46) | MTORRPTORMLST8PHGDHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |