Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.64 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.64 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133578 | 0.91 | MTOR (0.65) | MTORRPTORMLST8GRM5DRD4 | |
| Hydrochloric Acid SCHEMBL20141401 | 0.90 | MTOR (0.64) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL20133770 | 0.89 | MTOR (0.63) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL20133725 | 0.87 | MTOR (0.64) | MTORRPTORMLST8CHRM4 | |
| Hydrochloric Acid SCHEMBL20141684 | 0.86 | MTOR (0.64) | MTORRPTORMLST8CHRM4 | |
| SCHEMBL20140922 | 0.86 | MTOR (0.60) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL21360301 | 0.82 | MTOR (0.78) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL20150044 | 0.81 | MTOR (0.68) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL20149921 | 0.79 | MTOR (0.65) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL21340102 | 0.79 | MTOR (0.84) | MTORRPTORMLST8GRM5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |