Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141038 | 1.00 | KCNH2 (0.37) | KCNH2CHEK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20141029 | 0.94 | SLC6A2 (0.38) | KCNH2CHEK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20141216 | 0.89 | SLC6A2 (0.38) | KCNH2SLC6A2SLC6A4SLC6A3NOS3 | |
| SCHEMBL20141214 | 0.89 | SLC6A2 (0.38) | KCNH2SLC6A2SLC6A4SLC6A3NOS3 | |
| SCHEMBL20141147 | 0.88 | SLC6A2 (0.38) | KCNH2CHEK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20141030 | 0.86 | SLC6A2 (0.38) | CHEK1SLC6A2SLC6A4SLC6A3NOS3 | |
| SCHEMBL20140933 | 0.86 | SLC6A2 (0.36) | CHEK1SLC6A2SLC6A4SLC6A3NOS3 | |
| SCHEMBL20140875 | 0.83 | EZH2 (0.35) | KCNH2CHEK1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20140874 | 0.83 | EZH2 (0.35) | KCNH2CHEK1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20140898 | 0.83 | SLC6A4 (0.41) | KCNH2SLC6A2SLC6A4SLC6A3NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |