SCHEMBL20140933

SCHEMBL20140933

COC(=O)c1cc(N(c2ccccc2C#N)C2CCNCC2)c(C)cc1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 4/20 0.34
HPGD P15428 3/20 0.34
KDM4E B2RXH2 2/20 0.34
CRHBP P24387 2/20 0.34
CRHR2 Q13324 2/20 0.34
EZH2 Q15910 1/20 0.34
POLB P06746 1/20 0.33
KDM1A O60341 3/20 0.33
TDP1 Q9NUW8 1/20 0.33
CHEK1 O14757 1/20 0.33
CHEK2 O96017 1/20 0.33
GAA P10253 1/20 0.32
ADRA1D P25100 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
NOS2 P35228 2/20 0.32
NOS3 P29474 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20141030 0.93 SLC6A2 (0.38) SLC6A2SLC6A4SMN1; SMN2ALDH1A1HPGD
SCHEMBL20141029 0.91 SLC6A2 (0.38) SLC6A2SLC6A4SMN1; SMN2ALDH1A1HPGD
SCHEMBL20141353 0.89 SLC6A2 (0.39) SLC6A2SLC6A4EZH2KDM1ANOS2
SCHEMBL20141147 0.87 SLC6A2 (0.38) SLC6A2SLC6A4SMN1; SMN2ALDH1A1HPGD
SCHEMBL20141038 0.86 KCNH2 (0.37) SLC6A2SLC6A4SMN1; SMN2ALDH1A1HPGD
SCHEMBL20141036 0.86 KCNH2 (0.37) SLC6A2SLC6A4SMN1; SMN2ALDH1A1HPGD
SCHEMBL20141180 0.83 SLC6A2 (0.41) SLC6A2SLC6A4NOS2NOS3NOS1
SCHEMBL20141281 0.83 MTOR (0.35) SLC6A2SLC6A4ALDH1A1HPGDKDM4E
SCHEMBL20140898 0.82 SLC6A4 (0.41) SLC6A2SLC6A4NOS2NOS3NOS1
SCHEMBL20141342 0.82 SLC6A2 (0.36) SLC6A2SLC6A4EZH2POLBKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 EP disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed