Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.67 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.67 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.67 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133567 | 1.00 | MTOR (0.67) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL22693153 | 0.91 | MTOR (0.81) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL21360293 | 0.91 | MTOR (0.81) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL20141042 | 0.91 | MTOR (0.81) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL20133621 | 0.90 | MTOR (0.56) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL22693238 | 0.90 | MTOR (0.56) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL20141124 | 0.89 | MTOR (0.54) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL20133568 | 0.89 | MTOR (0.54) | MTORRPTORMLST8MLNRHCRTR1 | |
| SCHEMBL20149885 | 0.87 | MTOR (0.54) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20133727 | 0.83 | MTOR (0.73) | MTORRPTORMLST8HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |