Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133568 | 1.00 | MTOR (0.54) | MTORRPTORMLST8RETSYK | |
| SCHEMBL20133567 | 0.89 | MTOR (0.67) | MTORRPTORMLST8SYKKDM4E | |
| SCHEMBL20141116 | 0.89 | MTOR (0.67) | MTORRPTORMLST8SYKKDM4E | |
| SCHEMBL22693238 | 0.86 | MTOR (0.56) | MTORRPTORMLST8SYKHCRTR1 | |
| SCHEMBL20133621 | 0.86 | MTOR (0.56) | MTORRPTORMLST8SYKHCRTR1 | |
| SCHEMBL20133712 | 0.83 | MTOR (0.62) | MTORRPTORMLST8RET | |
| SCHEMBL20133838 | 0.83 | MTOR (0.62) | MTORRPTORMLST8RET | |
| SCHEMBL20149885 | 0.82 | MTOR (0.54) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20133565 | 0.82 | MTOR (0.81) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20133740 | 0.81 | MTOR (0.68) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |