Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141024 | 0.94 | MTOR (0.46) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20140814 | 0.91 | MTOR (0.45) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141403 | 0.89 | MTOR (0.43) | MTORRPTORMLST8HTR6PARP1 | |
| SCHEMBL20141317 | 0.89 | MTOR (0.46) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141741 | 0.88 | MTOR (0.42) | MTORRPTORMLST8TACR3EED | |
| SCHEMBL20141163 | 0.87 | MTOR (0.43) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141263 | 0.87 | MTOR (0.46) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20140851 | 0.86 | MTOR (0.44) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141169 | 0.85 | MTOR (0.45) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20140929 | 0.85 | MTOR (0.57) | MTORRPTORMLST8CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |